Conclusion Pregnancy by donor oocyte fertilization may entail a higher risk of eclampsia and associated posterior reversible encephalopathy syndrome.Objective Pain is the most frequently reported symptom involving in endometriosis. The alterations of neurotrophic factors and certain neuropeptides in the dorsal root ganglion (DRG), as well as serum and peritoneal fluid (PF), were evaluated in rat models of endometriosis. Materials and methods Twenty-four Sprague Dawley female rats were selected and maintained in a standard condition with 12 hours' dark-light cycles. All the rats were randomly assigned to 3 groups Control (intact rats); Sham (the operation was conducted without endometriosis induction); and Endometriosis (endometriosis induction was performed). The formalin test was performed for all groups on the first and the 21st day of the study. The assessments of Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), Calcitonin Gene-Related Peptide (CGRP), and Substance P levels were carried out by enzyme-linked immunosorbent assay (Elisa). The data were analyzed by One-Way ANOVA. The Tukey's test was used as post-hoc. https://www.selleckchem.com/products/pi3k-hdac-inhibitor-i.html Results Endometriosis induction significantly increased the mean pain scores in the endometriosis group in all three phases of the formalin test. The concentrations of DRG-CGRP (p=0.035), BDNF (p less then 0.001), and NGF (p=0.006) in the endometriosis group were significantly higher than that of the other groups while serum-BDNF (p less then 0.001), Substance P (p=0.009), and NGF (p=0.015) were significantly lower in endometriosis group compared to other groups. The concentrations of PF-BDNF (p=0.025) and Substance P (p=0.009) were significantly lower than those of other groups. Conclusion The present results delineate that endometriosis induction could lead to hyperalgesia. This may be related to the significant increases in the BDNF, NGF, and CGRP in DRG.Objective Pregnant women need health information to ensure their health and to have a healthy delivery. Therefore, equipping them with adequate information can bring desired health outcomes for them and their fetus. The present study was conducted to explore health information needs of women during pregnancy. Materials and methods The present research was a qualitative study. Thirty-nine participants (pregnant women, midwives, and obstetricians) were selected through purposeful sampling in Isfahan from June to November 2016. Data were collected through in-depth face-to-face semi-structured interviews, daily notes and field notes. Results Data analysis led to emergence of ten sub-categories including "common complaints during pregnancy", "problems and complications in pregnancy", "factors affecting fetal health", "proper nutrition and take supplements during pregnancy", "sex during pregnancy", "exercise during pregnancy", "diagnostic tests in pregnancy", "fetal growth and development", "types of childbirth and preparation for delivery" and "baby care and breastfeeding" and finally the main category was the "health information needs". Conclusion Regarding the health information requests of pregnant women, their needs should be identified and taken into consideration when planning educational programs for this group of women.Objective To develop a comprehensive antenatal risk assessment tool to predict adverse maternal and early perinatal outcomes in a rural setting. Materials and methods Cross-sectional study among women admitted for delivery in a rural maternity hospital, south India. Risk factors from Rotterdam Reproductive Risk Reduction (R4U) scorecard and social factors relevant to Indian rural context were included in questionnaire. Maternal and perinatal outcomes were obtained from in-patient records. Logistic regression of risk factors associated with adverse outcomes and weighted scores assigned using beta-coefficients. Cut-off score to predict adverse outcome was derived using Receiver Operator Characteristic Curve (ROC Curve) and Likelihood ratios. Results Adjusted odds for adverse outcome highest for small for gestational age by ultrasound scan [OR=7.4 (1.4-36.5)], tobacco chewing [OR=5.6 (1.8-28.5)] and hypertensive disorders of pregnancy [OR=3.5 (1.9-9.6)]. After assigning weighted scores, the 74-item antenatal risk assessment tool had a maximum possible score of 86. Risk score was calculated for all subjects. Cut-off score to predict adverse outcome was 4, using ROC curve, with a sensitivity of 98%, a specificity of 21% and positive likelihood ratio of 1.23 (1.10-1.37). Conclusion This comprehensive antenatal risk assessment tool is easy to administer, specific to rural areas and can help community-level workers to screen, monitor, and refer high risk pregnancies for further management to prevent adverse maternal and perinatal outcomes. This may be considered a prototype towards developing more robust antenatal risk screening and outcome prediction in rural settings.Objective To investigate the relationship between sex-composition of children and women's fertility desire in Vietnam. Materials and methods Using data from the 2014 Vietnam Multiple Indicator Cluster Survey (MICS), we investigate the association between sex composition of children and desire for additional children among women in reproductive age (15 to 49 years) across Vietnam (N=5,605). Results Multivariate logistic regression models showed statistically significant association between sex composition of children and women's fertility desire, after controlling for social norms of fertility preference, demographic and socioeconomic factors. For each group of women (those with one child, two children, and three or more children) women with no sons are more likely to have higher fertility desire compared to women with at least one son. However, women with both son (s) and daughter (s) tend to have lower fertility desire compared to those who have all sons. Conclusion Vietnam's traditional cultural norm of son preference has a strong influence on fertility desire. Besides, mix-gender preference is also documented. The government should enforce the law more strictly regarding the prohibition of ultrasounds to detect fetal sex to reduce the feasibility of sex selection abortion. In addition, the government should improve the social ideology of the role of women in the family and society through mass media.